Kotagiri, PrasantiMescia, FedericaHanson, Aimee LTurner, LorindaBergamaschi, LauraPeñalver, AnaRichoz, NathanMoore, Stephen DOrtmann, Brian MDunmore, Benjamin JMorgan, Michael DTuong, Zewen KelvinGöttgens, BertholdToshner, MarkHess, ChristophMaxwell, Patrick HClatworthy, Menna RNathan, James ABradley, John RLyons, Paul ABurrows, NatalieSmith, Kenneth G CCambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration2023-05-012023-05-012022-03-01Kotagiri, P, Mescia, F, Hanson, A L, Turner, L, Bergamaschi, L, Peñalver, A, Richoz, N, Moore, S D, Ortmann, B M, Dunmore, B J, Morgan, M D, Tuong, Z K, Göttgens, B, Toshner, M, Hess, C, Maxwell, P H, Clatworthy, M R, Nathan, J A, Bradley, J R, Lyons, P A, Burrows, N, Smith, K G C & Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration 2022, 'The impact of hypoxia on B cells in COVID-19', EBioMedicine, vol. 77, 103878. https://doi.org/10.1016/j.ebiom.2022.1038782352-3964PubMedCentral: PMC8856886ORCID: /0000-0003-0757-0711/work/141722666https://hdl.handle.net/2164/20597Acknowledgements We thank the patients and Health Care Workers who took part in this study. We are grateful for financial support from CVC Capital Partners, the Evelyn Trust (20/75), Addenbrooke’s Charitable Trust (12/20A) and the UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC). We acknowledge NIHR Cambridge BioResource Centre (Grant codes:RG85445 and RG94028), NIHR Cambridge Clinic Research Facility outreach team, relevant NHS Trusts and their staff, and the Wellcome Trust (no. 19710) for supporting murine studies. K.G.C.S. is the recipient of a Wellcome Investigator Award (200871/Z/16/Z); C.H. was funded by a Wellcome COVID-19 Rapid Response DCF and the Fondation Botnar. J.A.N is the recipient of a Wellcome Senior Clinical Research Fellowship (215477/Z/19/Z) and a Lister Institute Research Fellowship. NB and AP are supported by the Wellcome Trust, Senior Investigator Award to P.H.M, and the Rosetrees Trust. NR is supported by the NIHR Cambridge Biomedical Research Centre. Z.K.T. and M.R.C. are supported by a Medical Research Council Human Cell Atlas Research Grant (MR/S035842/1). M.R.C is supported by an NIHR Research Professorship (RP-2017-08-ST2-002). PK is the recipient of a Jacquot Research Entry Scholarship of the Royal Australasian College of Physicians Foundation. We thank the NIHR, NHS Blood and Transplant, and Health Data Research UK as part of the Digital Innovation Hub Programme, and the NIHR Cambridge Biomedical Research Centre Cell Phenotyping Hub, the CRUK Cambridge Institute cytometry core and the Cambridge NIHR BRC Stratified Medicine Core Laboratory NGS Hub.140189engSDG 3 - Good Health and Well-beingAnimalsCOVID-19HumansHypoxiaMiceOxygenPneumoniaSARS-CoV-2B cellsLymphopeniaR MedicineInfectious DiseasesCell BiologyImmunologyNational Institute for Health Research (NIHR)RG85445RG94028RP-2017-08-ST2-002UK Research and Innovation (UKRI)Wellcome Trust19710200871/Z/16/Z215477/Z/19/ZMedical Research Council (MRC)MR/S035842/1Supplementary DataRJournal article10.1016/j.ebiom.2022.10387877