Devereux, GrahamCotton, SeonaidhFielding, ShonaMcMeekin, NicolaBarnes, Peter J.Briggs, AndyBurns, GrahamChaudhuri, RekhaChrystyn, HenryDavies, LisaSoyza, Anthony DeGompertz, SimonHaughney, JohnInnes, KarenKaniewska, JoannaLee, AmandaMorice, AlynNorrie, JohnSullivan, AnitaWilson, AndrewPrice, David2019-08-232019-08-232019-07-31Devereux, G, Cotton, S, Fielding, S, McMeekin, N, Barnes, P J, Briggs, A, Burns, G, Chaudhuri, R, Chrystyn, H, Davies, L, Soyza, A D, Gompertz, S, Haughney, J, Innes, K, Kaniewska, J, Lee, A, Morice, A, Norrie, J, Sullivan, A, Wilson, A & Price, D 2019, 'Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations : a RCT', Health technology assessment (Winchester, England), vol. 23, no. 37, pp. 1-146. https://doi.org/10.3310/hta233701366-5278ORCID: /0000-0001-8512-4368/work/95223112ORCID: /0000-0002-4865-9061/work/159078075http://hdl.handle.net/2164/12765Acknowledgements We would like to thank all the participants who took part in the trial. We are grateful to all the staff at recruitment sites who facilitated identification, recruitment and follow-up of study participants (listed below). We are also grateful to other general practices and organisations that acted as PICs for the trial and practices that provided outcome data for trial participants who were unable to attend for follow-up. We could not have completed the trial without the ongoing support of local and primary care research networks: -NHS Research Scotland Primary Care Network (formerly Scottish Primary Care Research Network) – Amanda Cardy, Samantha Holden, Tracy Ibbotson, Yvonne McIlvenna, Marie Pitkethly, Janice Reid, Kim Stringer -North of England Commissioning Support (NECS) – Jeanette Dixon, Jill Ducker, Shona Haining, Gillian Johnson, Rachel Nixon, Norah Phipps, Cheryl Rigg - NIHR CRN South West Peninsula – Cate Atkins, Helen Clough, Tania Crabb, Patricia Hollway, Sara McNamara, Lisa Treeby, Lorraine Underwood - NIHR CRN Eastern – Lynne Baker, Brenda DeBoys, Kim Fell, Fenglin Guo, Emily Ikelle, Helen Jung, Heather Leishman, Rachel Lister, Lynn Mather, Cristina Page, Barbara Stewart - NIHR CRN Wessex Primary Care – Christine Brown - NIHR CRN Yorkshire and Humber – Carla Bratten -NIHR CRN North Thames – Mandy Austin, Carole Bartlett, Carol Keel, Helen McIver, Lucy Peppiatt. We thank Nadia Lewis-Burke for invaluable assistance in data checking. We are grateful to Georgia Mannion-Krase, Andrea Fraser and Lana Mitchell for their secretarial and data co-ordination support. We are grateful to Kirsty McCormack for her help and advice in developing the grant proposal. We thank Gladys McPherson, Mark Forrest and the programming team in CHaRT for developing and maintaining the trial website. We also thank Juliette Snow, Ruth Speedie and Rachel West for their help with contracting, and Louise Cotterell and Glenys Milton for their help in managing the budget. We are grateful for the guidance and support of the TSC (chairperson: Bill McNee; independent members: Matt Sydes, Mike Thomas, Alister Laird, Marion Middler) and the DMC chairperson: Hilary Pinnock; independent members: Chris Weir, Michael Steiner). We are also grateful to Bev Wears (British Lung Foundation) and Jacqueline Waters for helpful comments on early drafts of the trial documentation. We acknowledge Napp Pharmaceuticals Ltd for providing the trial drug (Uniphyllin, 200-mg modifiedrelease tablets) free of charge for use in the trial. The Health Services Research Unit and the Health Economics Research Unit are core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate.1461184057engSDG 3 - Good Health and Well-beingCOPDEXACERBATIONINHALED CORTICOSTEROIDSRANDOMISED CONTROLLED TRIALTHEOPHYLLINECOST-EFFECTIVENESSHISTONE DEACETYLASE ACTIVITYORAL THEOPHYLLINELUNG-FUNCTIONAIRWAY INFLAMMATIONEXACERBATION FREQUENCYINHALED FLUTICASONELOW-DOSE THEOPHYLLINEOBSTRUCTIVE PULMONARY-DISEASECOPD PATIENTSR MedicineHealth PolicyChief Scientist Office (CSO)RJournal article10.3310/hta23370http://www.scopus.com/inward/record.url?scp=85070488577&partnerID=8YFLogxK2337