Chakera, Ali J.Hurst, Paul S.Spyer, GillOgunnowo-Bada, Emmanuel O.Marsh, William J.Riches, Christine H.Yueh, Chen-YuMarkkula, S.PauliinaDalley, Jeffrey W.Cox, Roger D.Macdonald, Ian A.Amiel, Stephanie A.MacLeod, Kenneth M.Heisler, Lora K.Hattersley, Andrew T.Evans, Mark L.2018-11-022018-11-022018-11Chakera, A J, Hurst, P S, Spyer, G, Ogunnowo-Bada, E O, Marsh, W J, Riches, C H, Yueh, C-Y, Markkula, S P, Dalley, J W, Cox, R D, Macdonald, I A, Amiel, S A, MacLeod, K M, Heisler, L K, Hattersley, A T & Evans, M L 2018, 'Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes', Molecular Metabolism, vol. 17, pp. 17-27. https://doi.org/10.1016/j.molmet.2018.08.0012212-8778RIS: urn:6854C5EEC84F4100B3AC4E9B6E33C33Dhttp://hdl.handle.net/2164/11381111465234engSDG 3 - Good Health and Well-beingGlucokinaseHypoglycemiaCounter-regulationGlucagonEpinephrineInsulin clampMaturity Onset Diabetes of Young (MODY)β-cellsARCArcuate nucleusGEGlucose excitedGIGlucose inhibitedGCKHOMHomozygousHETHeterozygousSTZStreptozotocinVMNVentromedial hypothalamusWTWild typeR Medicine (General)R1Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetesJournal article10.1016/j.molmet.2018.08.001http://www.sciencedirect.com/science/article/pii/S221287781830750617