Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Woodley, KeithDillingh, LSGiotopoulos, GeorgeMadrigal, PedroRattigan, KMPhilippe, CélineDembitz, VilmaMagee, AMSAsby, Rvan de Lagemaat, Louie NMapperley, ChristopherJames, SCPrehn, JHMTzelepis, KonstantinosRouault-Pierre, KevinVassiliou, GeorgeKranc, KamilHelgason, G VignirHuntly, BJPGallipoli, Paolo2023-09-142023-09-142023-04-14Woodley, K, Dillingh, LS, Giotopoulos, G, Madrigal, P, Rattigan, KM, Philippe, C, Dembitz, V, Magee, AMS, Asby, R, van de Lagemaat, L N, Mapperley, C, James, SC, Prehn, JHM, Tzelepis, K, Rouault-Pierre, K, Vassiliou, G, Kranc, K, Helgason, G V, Huntly, BJP & Gallipoli, P 2023, 'Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.', Nature Communications, vol. 14, 2132. https://doi.org/10.1038/s41467-023-37652-02041-1723ORCID: /0000-0002-2947-1557/work/140168203https://hdl.handle.net/2164/21669Acknowledgements We wish to thank the Barts Cancer Institute tissue bank for sample collection and processing. This research was supported by the BCI Flow cytometry facility (CRUK Core Award C16420/A18066). This work was supported by the Wellcome Trust (PG, 109967/Z/15/Z), the American Society of Haematology (PG, Global Research Award) and Cancer Research UK (PG, Advanced Clinician Scientist fellowship, C57799/A27964). K.R-P. was supported by the Academy of Medical Sciences (SBF004\1099) J.H.M.P. was supported by a research grant from Science Foundation Ireland (SFI) under Grant Number 16/RC/3948 and co-funded under the European Regional Development Fund and by FutureNeuro industry partners. K.T. was funded by Wellcome Trust (Grant References: RG94424, RG83195, G106133), UKRI Medical Research Council (RG83195) and Leukaemia UK (G108148).191565762engSDG 3 - Good Health and Well-beingcancer metabolismcancer therapeutic resistanceR MedicineWellcome TrustPG, 109967/Z/15/ZRG94424RG83195Cancer Research UKC16420/A18066C57799/A27964G106133Medical Research Council (MRC)RG83195Supplementary DataRMannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.Journal article10.1038/s41467-023-37652-0https://europepmc.org/articles/PMC1010486114