IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

Dambuza, Ivy MHe, ChangChoi, Jin KyeongYu, Cheng-RongWang, RenxiMattapallil, Mary JWingfield, Paul TCaspi, Rachel REgwuagu, Charles E2018-11-202018-11-202017-09-28Dambuza, I M, He, C, Choi, J K, Yu, C-R, Wang, R, Mattapallil, M J, Wingfield, P T, Caspi, R R & Egwuagu, C E 2017, 'IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease', Nature Communications, vol. 8, 719. https://doi.org/10.1038/s41467-017-00838-42041-1723PubMedCentral: PMC5620058http://hdl.handle.net/2164/11477We thank Dr. Haohua Qian and Yichao Li (Visual function core, NEI, NIH) for technical assistance with OCT; Phyllis Silver (NEI, NIH) for EAU scoring of the eyes; Rashid Mahdi. M.J.M. for technical assistance with western blot analyses and Rafael Villasmil (NEI FLOW Cytometry Core facility) for assistance with FACS analysis.2437176engAnimalsAutoimmune Diseases/immunologyB-Lymphocytes, Regulatory/metabolismCell ProliferationImmunosuppressionInterleukin-10/metabolismInterleukin-12 Receptor beta 2 Subunit/metabolismInterleukin-12 Subunit p35/metabolismMice, Inbred C57BLMice, KnockoutProtein MultimerizationT-Lymphocytes, Regulatory/immunologyTh17 Cells/immunologyUveitis/immunologyQR180 ImmunologyQR180IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune diseaseJournal article10.1038/s41467-017-00838-48