Hijazi, KarolinIannelli, FrancescoCuppone, Anna MariaDesjardins, DelphineCaldwell, AnnaDereuddre-Bosquet, NathalieScala, CarloSmith, Kieron AMukhopadhya, IndraniFrank, BruceGwozdz, GarrySantoro, FrancescoLe Grand, RogerPozzi, GianniKelly, Charles G2021-02-042021-02-042020-03-02Hijazi, K, Iannelli, F, Cuppone, A M, Desjardins, D, Caldwell, A, Dereuddre-Bosquet, N, Scala, C, Smith, K A, Mukhopadhya, I, Frank, B, Gwozdz, G, Santoro, F, Le Grand, R, Pozzi, G & Kelly, C G 2020, 'In vivo modulation of cervicovaginal drug transporters and tissue distribution by film-released tenofovir and darunavir for topical prevention of HIV-1', Molecular Pharmaceutics, vol. 17, no. 3, pp. 852-864. https://doi.org/10.1021/acs.molpharmaceut.9b011211543-8384ORCID: /0000-0003-2577-518X/work/142142585https://hdl.handle.net/2164/15775We thank Gilead Science for provision of tenofovir and Janssen R&D Ireland for provision of darunavir. We thank members of the MOTIF consortium for useful discussions and exchange of ideas during the course of this study. We thank the technical staff of IDMIT, the animal care and veterinary staff at CEA, Fontenay-aux-Roses, France. Funding: this work was supported by the European Union's Seventh Programme for research, technological development and demonstration under grant agreement No 305316 as part of the MOTIF (Microbicides Formulation Through Innovative Formulation for Vaginal and Rectal Delivery) project. It has also the support of the “Investissements d’Avenir” French government program managed by the Agence Nationale de la Recherche under ANR-11-INBS-0008 funding for the Infectious Disease Models and Innovative Therapies (IDMIT, Fontenay-aux-Roses, France) infrastructure, and ANR-10-EQPX-02-01 funding for the FlowCyTech facility (IDMIT, Fontenay-aux-Roses, France).13511202engSDG 3 - Good Health and Well-beingMultidrug resistance associated proteintenofovirdarunavirmicrobicidesvaginamacaquesmultidrug resistance associated proteinCELLSPROTEASE INHIBITORSP-GLYCOPROTEINVAGINAL RINGSEFFLUX TRANSPORTERSREVERSE-TRANSCRIPTASE INHIBITORSDISOPROXIL FUMARATEINTRACELLULAR ACCUMULATIONMULTIDRUG-RESISTANCEEXPRESSIONR MedicineDrug DiscoveryMolecular MedicinePharmaceutical ScienceEuropean Commission305316Supplementary DataRJournal article10.1021/acs.molpharmaceut.9b01121http://www.scopus.com/inward/record.url?scp=85080093342&partnerID=8YFLogxK173