Kleeman, Sam O.Koelzer, Viktor H.Jones, Helen J.S.Vazquez, Ester GilDavis, HayleyEast, James E.Arnold, RolandKoppens, Martijn A.J.Blake, AndrewDomingo, EnricCunningham, ChrisBeggs, Andrew D.Pestinger, ValerieLoughrey, Maurice B.Wang, Lai-MunLannagan, Tamsin R.M.Woods, Susan L.Worthley, DanielThe S:CORT ConsortiumTomlinson, IanDunne, Philip D.Maughan, TimothyLeedham, Simon J.2020-05-122020-05-122019-09-28Kleeman, S O, Koelzer, V H, Jones, H J S, Vazquez, E G, Davis, H, East, J E, Arnold, R, Koppens, M A J, Blake, A, Domingo, E, Cunningham, C, Beggs, A D, Pestinger, V, Loughrey, M B, Wang, L-M, Lannagan, T R M, Woods, S L, Worthley, D, The S:CORT Consortium, Tomlinson, I, Dunne, P D, Maughan, T & Leedham, S J 2019, 'Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification', Gut, vol. 69, pp. 1092-1103. https://doi.org/10.1136/gutjnl-2019-3191260017-5749RIS: urn:FACD63D229080594612105E9F5EFF426ORCID: /0000-0003-3981-2420/work/76973667unpaywall: 10.1136/gutjnl-2019-319126https://hdl.handle.net/2164/14310Acknowledgments The authors would like to thank Graeme Murray for provision of the rectal cancer biopsies under licence from the Grampian biorepository, to Matt Seymour for use of the FOCUS trial samples and to the MRC FOCUS trial management group. Funding: This work was supported by Wellcome Trust Senior Clinical Research Fellowship (206314/Z/17/Z) and Worldwide Cancer Research grant (16-0042) to SJL, the Stratification in Colorectal Cancer (S:CORT) Consortium, which is funded by the Medical Research Council and Cancer Research UK and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. VHK was funded by the Swiss National Science Foundation (P2SKP3_168322/1 and P2SKP3_168322/2). HJSJ was supported by a Bowel Disease Research Foundation (BDRF) research grant. ADB is funded by a Cancer Research UK Advanced Clinician Scientist award (C31641/A23923) and the Wellcome Trust (102732/Z/13/Z). TRML, SLW and DW supported by the NHMRC, Beat Cancer SA & Cure Cancer Australia. JEE was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). Core funding to the Wellcome Trust Centre for Human Genetics was provided by the Wellcome Trust (090532/Z/09/Z). Data availability statement: Data relating to transcriptome profiling of relevant genes in polyps cohort and validation cohorts A/B are available online (https://www.s-cort.org/exploiting-differential-wnt). All other data relevant to the study are referenced, included in the article or uploaded as supplementary information.1215168043engSDG 3 - Good Health and Well-beingAXIN2colorectal cancermolecular biomarkerstratificationWnt signallingRNF43COLONFUSIONSMUTATIONSTUMORSR Medicine (General)GastroenterologyMedical Research Council (MRC)Cancer Research UKC31641/A23923Other16-0042National Institute for Health Research (NIHR)Wellcome Trust206314/Z/17/Z102732/Z/13/Z090532/Z/09/ZSupplementary DataR1Journal article10.1136/gutjnl-2019-319126http://www.scopus.com/inward/record.url?scp=85084379743&partnerID=8YFLogxK69