Mu, XiaojingMurakami, HajimeMohibullah, NeemanKeeny, Scott2023-05-012023-05-012020-11Mu, X, Murakami, H, Mohibullah, N & Keeny, S 2020, 'Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation', Genes & Development, vol. 34, pp. 1605-1618. https://doi.org/10.1101/gad.342873.1200890-9369ORCID: /0000-0002-7022-6887/work/83374366https://hdl.handle.net/2164/20598We are grateful to Michael Lichten and Rodney Rothstein for providing strains and plasmids, Miki Shinohara and Keun Kim for discussions and sharing unpublished data, Dean Dawson and Amy MacQueen for sharing unpublished data, Agnes Viale (Memorial Sloan Kettering Cancer Center [MSKCC] Integrated Genomics Core Laboratory) for sequencing, Nicholas Socci (MSKCC Bioinformatics Core Facility) for mapping sequence reads, Stewart Shuman for gifts of T4 RNA ligase, and members of the S.K. laboratory, especially Shintaro Yamada and Devanshi Jain, for discussion and comments on the manuscript. MSKCC core facilities are supported by Cancer Center Support Grant P30 CA008748. This work was supported by National Institute of General Medical Sciences grant R35 GM118092 to S.K. Author contributions: X.M. performed experiments. X.M. analyzed Spo11-oligo map data with contributions from H.M. N.M. generated the Spo11-oligo map of the trisomy XV strain. X.M., H.M., and S.K. designed the study and wrote the paper. H.M. and S.K. supervised the research. S.K. secured funding152396388enganeuploidydouble-strand breaksmeiosisrecombinationtrisomysynaptonemal complexSpo11R MedicineSupplementary InformationSupplemental material is available for this articleRJournal article10.1101/gad.342873.120http://dx.doi.org/10.1101/gad.342873.12034