Hwang, Dong-JinHe, YaliPonnusamy, SuriyanMohler, Michael L.Thiyagarajan, ThirumagalMcEwan, Iain J.Narayanan, RameshMiller, Duane D.2019-12-072019-12-072019Hwang, D-J, He, Y, Ponnusamy, S, Mohler, M L, Thiyagarajan, T, McEwan, I J, Narayanan, R & Miller, D D 2019, 'A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity', Journal of Medicinal Chemistry, vol. 62, no. 2, pp. 491-511. https://doi.org/10.1021/acs.jmedchem.8b009730022-2623Mendeley: e33a8904-4279-3ba8-81b2-33bcabb8b594https://hdl.handle.net/2164/13357This research was supported by the Van Vleet Endowed Professorship (D.D.M.), and GTx, Inc. grant (R.N. and D.D.M.) We thank GTx, Inc. for supporting this project and Dr. Dejian Ma of UTHSC, College of Pharmacy for assistance with 2D NMR and HRMS experiments.202075694engSDG 3 - Good Health and Well-beingstructure-activity relationshipselective androgen receptor degraderandrogen receptorandrogen receptor splice variantAR-V7AR escape mutantsAntagonistprostate cancerAntiandrogen resistanceEnzalutamide resistanceCastration-resistant prostate cancerN-terminal domainLigand binding domainProstate-specific antigenAR activation function domain-1R Medicine (General)Drug DiscoveryMolecular MedicineSupplementary Datasupplementary data availableR1Journal article10.1021/acs.jmedchem.8b00973http://www.scopus.com/inward/record.url?scp=85059636744&partnerID=8YFLogxKhttp://www.mendeley.com/research/new-generation-selective-androgen-receptor-degraders-initial-design-synthesis-biological-evaluation622