Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes

Khatib, ThabatChisholm, David RWhiting, AndrewPlatt, BettinaMcCaffery, Peter2020-02-072020-02-072020-02-04Khatib, T, Chisholm, D R, Whiting, A, Platt, B & McCaffery, P 2020, 'Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes', Journal of Alzheimer's Disease, vol. 73, no. 3, pp. 935-954. https://doi.org/10.3233/JAD-1909311387-2877ORCID: /0000-0002-5956-3997/work/76974670ORCID: /0000-0002-7852-0749/work/76976885https://hdl.handle.net/2164/13673Support was received from BBSRC grant (BB/P004806/1), Alzheimer’s Society grant (AS-PG-14-039), ARUK grant (ARUK-PG2017B-11) and NHS Grampian.202145975engSDG 3 - Good Health and Well-beingAldh1a2amyloid chemokinescholesterolcyp26a1cyp26b1growth factorNos2stra6TnfIL-1-INDUCED IL-6 PRODUCTIONOXIDATIVE STRESSDIFFERENTIAL EXPRESSIONRELATIONAL MEMORY DEFICITchemokinesHIPPOCAMPAL-NEURONSVITAMIN-ACOGNITIVE DECLINEamyloidAMYLOID-BETAUP-REGULATIONTRANSGENIC MICERC0321 Neuroscience. Biological psychiatry. NeuropsychiatryGeriatrics and GerontologyPsychiatry and Mental healthClinical PsychologyGeneral NeuroscienceBiotechnology and Biological Sciences Research Council (BBSRC)BB/P004806/1Arthritis Research UK (ARUK)PG2017B-11Supplementary DataRC0321Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective GenesJournal article10.3233/JAD-190931http://www.scopus.com/inward/record.url?scp=85079203406&partnerID=8YFLogxK733