Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

Walker, Louise ALee, KeunsookMunro, Carol AGow, Neil A R2015-09-232015-09-232015-10Walker, L A, Lee, K, Munro, C A & Gow, N A R 2015, 'Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies', Antimicrobial Agents and Chemotherapy, vol. 59, no. 10, pp. 5932-5941. https://doi.org/10.1128/AAC.00862-150066-4804ORCID: /0000-0002-2236-8776/work/100346473ORCID: /0000-0003-0761-1755/work/162729028http://hdl.handle.net/2164/4935Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.101558532engchitindrug resistanceechinocandinfungal cell wallsignal transductionQR MicrobiologyQRCaspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich MicrocoloniesJournal article10.1128/AAC.00862-155910