Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model

Barton, Samantha K.Gregory, JennaMagnani, DarioJames, Owen G.Livesey, Matthew R.Selvaraj, Bhuvaneish T.James, Owain T.Perkins, Emma M.Cleary, Elaine M.Ausems, C Rosanne MCarter, Roderick N.Vasistha, Navneet A.Zhao, Chen-RuBurr, KarenStory, DavidCardinali, AlessandraMorton, Nicholas M.Hardingham, Giles E.Wyllie, David J. A.Chandran, Siddharthan2022-07-072022-07-072021Barton, S K, Gregory, J, Magnani, D, James, O G, Livesey, M R, Selvaraj, B T, James, O T, Perkins, E M, Cleary, E M, Ausems, C R M, Carter, R N, Vasistha, N A, Zhao, C-R, Burr, K, Story, D, Cardinali, A, Morton, N M, Hardingham, G E, Wyllie, D J A & Chandran, S 2021, 'Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model', Brain Communications, vol. 3, no. 4, fcab255. https://doi.org/10.1093/braincomms/fcab2552632-1297ORCID: /0000-0003-3337-4079/work/112144204https://hdl.handle.net/2164/18814Acknowledgements The authors kindly acknowledge the technical expertise and assistance of Ms Nicola Miller and Ms Karen Gladstone. Graphical abstract was created using BioRender.com. Funding This research was supported by the Wellcome Trust (092742/Z/10/Z), MND Association (Miles/Oct14/878– 792), SC lab is supported by the Euan MacDonald Centre for Motor Neurone Disease Research, and the UK Dementia Research Institute (DRI), which receives its funding from UK DRI Ltd, funded by the MRC, Alzheimer’s Society and Alzheimer’s Research UK. SC also acknowledges funding from the ARRNC, Department of Biotechnology India, University of Edinburgh Institutional Strategic Support Fund. Royal Society of Edinburgh (M.R.L), WT NIA 100981/Z/ 13/Z (N.M.M.), ARRNC (B.T.S) and an Australian National Health and Medical Research (NH&MRC) and Australian Research Council (ARC) Dementia Research Development Fellowship (S.K.B.: 1110040)121377419engamyotrophic lateral sclerosisoligodendrocytesTDP-43induced pluripotent stem cellRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryWellcome Trust092742/Z/10/ZOther(Miles/Oct14/878– 792Supplementary DataRC0321Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell modelJournal article10.1093/braincomms/fcab255http://dx.doi.org/10.1093/braincomms/fcab25534