A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives

Lazzari, PaoloDistinto, RitaManca, IlariaBaillie, GemmaMurineddu , GabrielePira, MarilenaFalzoi, MatteoSani, MonicaMorales, PaulaRoss, RuthZanda, MatteoJagerovic , NadinePinna, Gerard Aime2017-05-062017-05-062016-10-04Lazzari, P, Distinto, R, Manca, I, Baillie, G, Murineddu , G, Pira, M, Falzoi, M, Sani, M, Morales, P, Ross, R, Zanda, M, Jagerovic , N & Pinna, G A 2016, 'A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives', European Journal of Medicinal Chemistry, vol. 121, pp. 194-208. https://doi.org/10.1016/j.ejmech.2016.05.0110223-5234http://hdl.handle.net/2164/8608We thank European Commission (project “PET BRAIN: Mapping the brain with PET radiolabeled cannabinoid CB1 ligands”; FP7-People-2009-IAPP; Grant Agreement N.25142).15894741engcannabinoidsendocannabinoid system (ECS)8-chloro-1-(2’,4’-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamidecannabinoid receptor binding assaysCB1 receptor ligandsQH301 BiologyQH301A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivativesJournal article10.1016/j.ejmech.2016.05.011121