Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Pollack, Saskia J.Trigg, JasmineKhanom, TahmidaBiasetti, LucaMarshall, Karen E.Al-Hilaly, Youssra K.Rickard, Janet E.Harrington, Charles R.Wischik, Claude M.Serpell, Louise C.2020-08-042020-08-042020-08-07Pollack, S J, Trigg, J, Khanom, T, Biasetti, L, Marshall, K E, Al-Hilaly, Y K, Rickard, J E, Harrington, C R, Wischik, C M & Serpell, L C 2020, 'Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells', Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907. https://doi.org/10.1016/j.jmb.2020.05.0270022-2836ORCID: /0000-0003-2250-3920/work/173415879https://hdl.handle.net/2164/14862Acknowledgements The authors wish to thank Dr Pascale Schellenberger for technical help with transmission electron microscopy. The authors are grateful for valuable experimental support from Dr Mahmoud Bukar Maina. SJP was supported by a Sussex Neuroscience doctoral grant. KEM was supported by Medical Research Council (MR/K022105/1) awarded to LCS. LCS is supported by funding from Alzheimer’s Research UK and Alzheimer’s Society and Biotechnology and Biological Sciences Research Council (BB/S003657/1) Funding SJP was supported by a Sussex Neuroscience doctoral grant. KEM was supported by Medical Research Council (MR/K022105/1) awarded to LCS. LCS is supported by funding from Alzheimer’s Research UK and Alzheimer’s Society and Biotechnology and Biological Sciences Research Council (BB/S003657/1). KEM and YKA were supported by funding from WisTa Laboratories Ltd. (PAR1596).173386947engtauAlzheimer’s diseasepropagationaggregationAlzheimer's diseaseALZHEIMERS-DISEASETAUOPATHYPATHOLOGYAUTOPHAGYOLIGOMERSIN-VITROFIBRILSPROPAGATIONAGGREGATIONSYNTHETIC TAUR Medicine (General)Molecular BiologyStructural BiologyMedical Research Council (MRC)MR/K022105/1Alzheimers Research UKBiotechnology and Biological Sciences Research Council (BBSRC)BB/S003657/1R1Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cellsJournal article10.1016/j.jmb.2020.05.027http://www.scopus.com/inward/record.url?scp=85088780669&partnerID=8YFLogxK43217