McEwan, Andrew RDavidson, ConnorHay, ElizabethTurnbull, YvonneErickson, Johanna CeleneMarini, PietroWilson, DanaMcIntosh, AndrewAdams, Mark J.Murgatroyd, ChrisBarrett, PerryDelibegovic, MirelaClarke, Toni-KimMacKenzie, Alasdair2020-09-122020-09-122021-06McEwan, A R, Davidson, C, Hay, E, Turnbull, Y, Erickson, J C, Marini, P, Wilson, D, McIntosh, A, Adams, M J, Murgatroyd, C, Barrett, P, Delibegovic, M, Clarke, T-K & MacKenzie, A 2021, 'CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake', Molecular Psychiatry, vol. 26, pp. 2263–2276. https://doi.org/10.1038/s41380-020-0707-71359-4184ORCID: /0000-0003-3604-2950/work/76975742ORCID: /0000-0001-6193-3152/work/160847592ORCID: /0000-0002-8456-4473/work/177758651https://hdl.handle.net/2164/15125We would like to thank Wenlong Huang, Giuseppe D’Agostino and the staff of the University of Aberdeen Medical Research Facility for their help and advice with the animal tests. AMcE was funded by BBSRC project grant (BB/N017544/1) and EH was funded by Medical Research Scotland (PhD-719-2013). PB and DW are funded by the Scottish Government Rural and Environment Science and Analytical Services Division to the Rowett Institute. Association studies were conducted using the UK Biobank Resource: application number 4844 and was supported by a Wellcome Trust Strategic Award ‘Stratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). Dedicated to the memory of my dear brother Angus MacKenzie (1963–2018).149385678engOutside of REF 2029 publication periodSDG 3 - Good Health and Well-beingUK BiobankCRISPR genome editingtissue-specific enhancergalaninethanol intakePKCEGR1male anxietyDEPRESSIONREMOTE ENHANCERDISORDERSDEPENDENCEPARAVENTRICULAR NUCLEUSGALANINGENE-EXPRESSIONCONSUMPTIONRANGEHYPOTHALAMUSR MedicinePsychiatry and Mental healthCellular and Molecular NeuroscienceMolecular BiologyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N017544/1Wellcome Trust104036/Z/14/ZSupplementary DataRJournal article10.1038/s41380-020-0707-7http://www.scopus.com/inward/record.url?scp=85082181124&partnerID=8YFLogxK