Luna-Viramontes, Nabil ItziCampa-Córdoba, B. BereniceOntiveros-Torres, Miguel AngelHarrington, Charles RVillanueva-Fierro, IgnacioGuadarrama-Ortíz, ParménidesGarcés-Ramírez, Lindade la Cruz, FidelHernandes-Alejandro, MarioMartínez-Robles, SandraGonzález-Ballesteros, ErikPacheco-Herrero, MarLuna-Muñoz, José2020-10-232020-10-232020-09-10Luna-Viramontes, N I, Campa-Córdoba, B B, Ontiveros-Torres, M A, Harrington, C R, Villanueva-Fierro, I, Guadarrama-Ortíz, P, Garcés-Ramírez, L, de la Cruz, F, Hernandes-Alejandro, M, Martínez-Robles, S, González-Ballesteros, E, Pacheco-Herrero, M & Luna-Muñoz, J 2020, 'PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease', Frontiers in cellular neuroscience, vol. 14, 247. https://doi.org/10.3389/fncel.2020.002471662-5102ORCID: /0000-0003-2250-3920/work/173415888https://hdl.handle.net/2164/15277FUNDING This work was supported by Fondo Nacional de Ciencia, Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015- 3A2-127 to MP-H and 2018-2019-2A3-208 to JL-M and MP-H). ACKNOWLEDGMENTS: We want to express our gratitude to the following: Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, United States) and Lester I. Binder† (North Western, Chicago, IL, United States) for the generous gifts of mAbs TG3 and Alz-50, and Tau-1, Tau-5, and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; Samadhi Moreno-Campuzano for her technical assistance/support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medical University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer’s disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López† .113223640engtau proteintau pathologyPHF coreTruncationphosphorylationconformational changespaired helical filamentneurofibrillary tanglestruncationR MedicineCellular and Molecular NeuroscienceRJournal article10.3389/fncel.2020.00247http://www.scopus.com/inward/record.url?scp=85091531587&partnerID=8YFLogxK14