Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trial

Morrow, Gael B.Feller, TimeaMcQuilten, ZoeWake, ElizabethAriëns, Robert A. S.Winearls, JamesMutch, Nicola J.Laffan, Mike A.Curry, Nicola2022-10-022022-10-022022-09-26Morrow, G B, Feller, T, McQuilten, Z, Wake, E, Ariëns, R A S, Winearls, J, Mutch, N J, Laffan, M A & Curry, N 2022, 'Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trial', Critical Care, vol. 26, no. 1, 290. https://doi.org/10.1186/s13054-022-04167-x1364-8535RIS: urn:474282ECCD3E9944BD3ECAAFBF31EB93RIS: Morrow2022ORCID: /0000-0001-9299-6754/work/120222482ORCID: /0000-0002-7452-0813/work/169538898https://hdl.handle.net/2164/19263Acknowledgements We acknowledge the Aberdeen Microscopy and Histology Core Facility and thank Judith de Vries for her guidance in analysing the confocal images. We thank Megan Simpson for measuring PAI-1 and uPA antigen levels in the fibrinogen preparations. We thank all of the FEISTY research staff who collected and processed the patient samples. Funding This work was supported by research grants from CSL Behring and Tenovus Scotland.122371013engFibrinogencryoprecipitateclot structureTrauma coagulopathyfibrinolysisR Medicine (General)Supplementary InformationSupplementary DataDASR1Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trialJournal article10.1186/s13054-022-04167-x261