Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Wagener, JeanetteMalireddi, R K SubbaraoLenardon, Megan DKöberle, MartinVautier, SimonMacCallum, Donna MBiedermann, TiloSchaller, MartinNetea, Mihai GKanneganti, Thirumala-DeviBrown, Gordon DBrown, Alistair J PGow, Neil A R2014-09-082014-09-082014-04-10Wagener, J, Malireddi, R K S, Lenardon, M D, Köberle, M, Vautier, S, MacCallum, D M, Biedermann, T, Schaller, M, Netea, M G, Kanneganti, T-D, Brown, G D, Brown, A J P & Gow, N A R 2014, 'Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation', PLoS Pathogens, vol. 10, no. 4, e1004050. https://doi.org/10.1371/journal.ppat.10040501553-7366ORCID: /0000-0003-4833-0378/work/47631072ORCID: /0000-0002-7227-4348/work/40417674http://hdl.handle.net/2164/3463Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported by a Vici grant of the Netherlands Organisation for Scientific Research. AJPB and DMM were funded by STRIFE, ERC-2009-AdG-249793 and AJPB additionally by FINSysB, PITN-GA-2008-214004 and the BBSRC [BB/F00513X/1]. MDL was supported by the MRC (MR/J008230/1). GDB and SV were funded by the Wellcome Trust (086558) and TB and MK were funded by the Deutsche Forschungsgemeinschaft (Bi 696/3-1; Bi 696/5-2; Bi 696/10-1). MS was supported by the Deutsche Forschungsgemeinschaft (Sch 897/1-3) and the National Institute of Dental and Craniofacial Research (R01 DE017514-01). TDK and RKSM were funded by the National Institute of Health (AR056296, AI101935) and the American Lebanese Syrian Associated Charities (ALSAC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.151957781engSDG 3 - Good Health and Well-beingChitinSecretionCandida albicansCytokinesMacrophagesCell wallsInflammationFungal phatogensQR MicrobiologyWellcome Trust086827080088075470097377086558European CommissionFP7/2007 2013HEALTH-2010-260338European Research CouncilERC-2009-AdG-249793Biotechnology and Biological Sciences Research Council (BBSRC)BB/F00513X/1Medical Research Council (MRC)MR/J008230/1Supplementary DataQRFungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 ActivationJournal article10.1371/journal.ppat.1004050104