Hopewell, SallyChan, An-WenCollins, Gary SHróbjartsson, AsbjørnMoher, DavidSchulz, Kenneth FTunn, RuthAggarwal, RakeshBerkwits, MichaelBerlin, Jesse ABhandari, NitaButcher, Nancy JCampbell, Marion KChidebe, Runcie C WElbourne, DianaFarmer, AndrewFergusson, Dean AGolub, Robert MGoodman, Steven NHoffmann, Tammy CIoannidis, John P AKahan, Brennan CKnowles, Rachel LLamb, Sarah ELewis, SteffLoder, ElizabethOffringa, MartinRavaud, PhilippeRichards, Dawn PRockhold, Frank WSchriger, David LSiegfried, Nandi LStaniszewska, SophieTaylor, Rod SThabane, LehanaTorgerson, DavidVohra, SunitaWhite, Ian RBoutron, Isabelle2025-07-162025-07-162025-04-14Hopewell, S, Chan, A-W, Collins, G S, Hróbjartsson, A, Moher, D, Schulz, K F, Tunn, R, Aggarwal, R, Berkwits, M, Berlin, J A, Bhandari, N, Butcher, N J, Campbell, M K, Chidebe, R C W, Elbourne, D, Farmer, A, Fergusson, D A, Golub, R M, Goodman, S N, Hoffmann, T C, Ioannidis, J P A, Kahan, B C, Knowles, R L, Lamb, S E, Lewis, S, Loder, E, Offringa, M, Ravaud, P, Richards, D P, Rockhold, F W, Schriger, D L, Siegfried, N L, Staniszewska, S, Taylor, R S, Thabane, L, Torgerson, D, Vohra, S, White, I R & Boutron, I 2025, 'CONSORT 2025 statement : updated guideline for reporting randomised trials', BMJ (Clinical research ed.), vol. 389, e081123. https://doi.org/10.1136/bmj-2024-0811230959-8146PubMedCentral: PMC11995449ORCID: /0000-0001-5386-4097/work/188766878https://hdl.handle.net/2164/25713SPIRIT-CONSORT executive group: Sally Hopewell, University of Oxford, UK; An-Wen Chan, University of Toronto, Canada; Asbjørn Hróbjartsson, University of Southern Denmark, Odense, Denmark; David Moher, University of Ottawa, Canada; Kenneth Schulz, University of North Carolina at Chapel Hill, USA; Isabelle Boutron, Université Paris Cité, France. Gary Collins and Ruth Tunn, both of University of Oxford, UK, were also involved in leading the SPIRIT and CONSORT 2025 update. SPIRIT-CONSORT 2025 consensus meeting participants: Rakesh Aggarwal, Jawaharlal Institute of Postgraduate Medical Education and Research, India; Michael Berkwits, Office of the Centers for Disease Control and Prevention, USA (formally JAMA and the JAMA Network at time of consensus meeting); Jesse A Berlin, Rutgers University/JAMA Network Open USA; Nita Bhandari, Society for Applied Studies, India; Nancy J Butcher, The Hospital for Sick Children, Canada; Marion K Campbell, University of Aberdeen, UK; Runcie CW Chidebe, Project PINK BLUE, Nigeria/Miami University, Ohio, USA; Diana Elbourne, London School of Hygiene and Tropical Medicine, UK; Andrew J Farmer, University of Oxford, UK; Dean A Fergusson, Ottawa Hospital Research Institute, Canada; Robert M Golub, Northwestern University, USA; Steven N Goodman, Stanford University, USA; Tammy C Hoffmann, Bond University, Australia; John PA Ioannidis, Stanford University, USA; Brennan C Kahan, University College London, UK; Rachel L Knowles, University College London, UK; Sarah E Lamb, University of Exeter, UK; Steff Lewis, University of Edinburgh, UK; Elizabeth Loder, The BMJ, UK; Martin Offringa, Hospital for Sick Children Research Institute, Canada; Dawn P Richards, Clinical Trials Ontario, Canada; Frank W Rockhold, Duke University, USA; David L Schriger, University of California, USA; Nandi L Siegfried, South African Medical Research Council, South Africa; Sophie Staniszewska, University of Warwick, UK; Rod S Taylor, University of Glasgow, UK; Lehana Thabane, McMaster University/St Joseph’s Healthcare, Canada; David Torgerson, University of York, UK; Sunita Vohra, University of Alberta, Canada; and Ian R White, University College London, UK. We dedicate CONSORT 2025 to the late Doug Altman who was instrumental in the development of the SPIRIT and CONSORT statements and whose files and correspondence contributed to this update following his death. We gratefully acknowledge the contributions of all those who participated in the SPIRIT-CONSORT 2025 update Delphi survey. We also acknowledge Camilla Hansen Nejstgaard for conducting the scoping review of the literature to identify suggested changes to CONSORT 2010 and for comparing CONSORT 2025 with RoB2, Lasse Østengaard for developing the SCEB (SPIRIT-CONSORT Evidence Bibliographic) database of empirical evidence to support the development of CONSORT, Jen de Bayer and Patricia Logullo for their involvement during the consensus meeting, and Lina El Ghosn for initial drafting of the expanded CONSORT checklist. The CONSORT 2025 statement is being simultaneously published in The BMJ, JAMA, The Lancet, Nature Medicine, and PLOS Medicine.9319226engRandomized Controlled Trials as Topic/standardsHumansChecklist/standardsPublishing/standardsGuidelines as TopicResearch Report/standardsResearch Design/standardsDelphi TechniqueRA Public aspects of medicineRAJournal article10.1136/bmj-2024-081123389