Khanshour, Anas MKidane, YaredKozlitina, JuliaCornelia, ReuelRafipay, AlexandraDe Mello, VanessaWeston, MitchellParia, NandinaKhalid, AyshaHecht, Jacqueline TDobbs, Matthew BRichards, B. StephensVargesson, NeilKent Hamra, FWilson, MeganWise, CarolGurnett, Christina ARios, Jonathan J2021-10-252021-10-252020-11-15Khanshour, A M, Kidane, Y, Kozlitina, J, Cornelia, R, Rafipay, A, De Mello, V, Weston, M, Paria, N, Khalid, A, Hecht, J T, Dobbs, M B, Richards, B S, Vargesson, N, Kent Hamra, F, Wilson, M, Wise, C, Gurnett, C A & Rios, J J 2020, 'Genetic association and characterization of FSTL5 in isolated clubfoot', Human Molecular Genetics, vol. 29, no. 22, pp. 3717-3728. https://doi.org/10.1093/hmg/ddaa2360964-6906ORCID: /0000-0001-8027-114X/work/145270753https://hdl.handle.net/2164/17391ACKNOWLEDGEMENTS: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). The authors thank the staff and participants of the ARIC study for their important contributions. Funding for GENEVA was provided by National Human Genome Research Institute grant U01HG004402 (E.Boerwinkle). We thank H. Hobbs and J. Cohen for contributing control samples for replication genotyping, Nadav Ahituv for sharing RNA-seq data for both bat and mouse embryonic limb buds, Tommy Hyatt for designing the custom genotyping assay, and members of the UT Southwestern Transgenic Core facility, including John Ritter, Mylinh Nguyen, and Robert Hammer. Publicly available mouse embryonic expression analysis results were provided online at https://oncoscape.v3.sttrcancer.org/atlas.gs.washington.edu.mouse.rna/landing (24). The authors acknowledge the contributions and support of the Center for Excellence in Clubfoot Research at Scottish Rite for Children, including Shawne Faulks and Kristhen Atala. Fstl5 mutant rats were produced by the NIH Mutant Rat Resource at UT Southwestern Medical Center (R24RR03232601, R24OD011108, R01HD036022, and (5R01HD053889). This study was supported by funding from the Scottish Rite for Children Research Fund (J.J.R.), Shriners Hospital for Children (J.T.H), and the National Institutes of Health award R01HD043342 (J.T.H.).12413571enggenome-wide association studyclubfootFSTL5imputationR MedicineRJournal article10.1093/hmg/ddaa2362922