Reed, Austin DPensa, SaraSteif, AdiStenning, JackKunz, Daniel JPorter, Linsey JHua, KuiHe, PengTwigger, Alecia-JaneSiu, Abigail J QKania, KatarzynaBarrow-McGee, RachelGoulding, IainGomm, Jennifer JSpeirs, ValerieJones, J LouiseMarioni, John CKhaled, Walid T2024-04-252024-04-252024-04Reed, A D, Pensa, S, Steif, A, Stenning, J, Kunz, D J, Porter, L J, Hua, K, He, P, Twigger, A-J, Siu, A J Q, Kania, K, Barrow-McGee, R, Goulding, I, Gomm, J J, Speirs, V, Jones, J L, Marioni, J C & Khaled, W T 2024, 'A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast', Nature Genetics, vol. 56, no. 4, pp. 652-662. https://doi.org/10.1038/s41588-024-01688-91061-4036ORCID: /0000-0002-0602-4666/work/158672372https://hdl.handle.net/2164/23344A.D.R. performed the majority of the bioinformatic analysis and interpretation of the data. S.P. contributed to the study design, sample processing, analysis and interpretation of the data. J.S. contributed to the sample processing. D.J.K. and P.H. contributed to the data processing, batch correction and cell cluster identification. A.S. contributed to the design of the sample batches and contributed to the analysis of the raw data. A.J.T. contributed to the analysis of the data and Figure design. L.J.P. performed the immune histochemistry validations. K.H. assisted A.D.R. with the inferCNV analysis and interpretation. P.H. assisted with the subclustering of immune cells and scVI integration analysis. A.Q.S. performed the immunofluorescence quantification. K.K. performed all the scRNA-seq library preparation and sequencing. R.B.M., I.G., J.J.G., V.S. and J.L.J. provided the human tissues and the metadata from the 55 donors. A.D.R., S.P., J.C.M. and W.T.K. wrote the paper. J.C.M. and W.T.K. conceptualized and supervised the study.1118704374engSDG 3 - Good Health and Well-beingAdultBRCA1 Protein/geneticsBRCA2 Protein/geneticsBreast Neoplasms/geneticsFemaleGenes, BRCA2Germ-Line MutationHumansPregnancyR Medicine (General)GeneticsSupplementary DataR1Journal article10.1038/s41588-024-01688-9http://www.scopus.com/inward/record.url?scp=85188941203&partnerID=8YFLogxK564