Mcewan, AndrewHay, ElisabethDavidson, ConnorTurnbull, YvonneErickson, Johanna CeleneMarini, PietroWilson, DanaMcIntosh, Andrew M.Adams, Mark J.Murgatroyd, ChrisBarrett, PerryDelibegovic, MirelaClarke, Toni-KimMacKenzie, Alasdair2021-02-102021-02-102019-12-13Mcewan, A, Hay, E, Davidson, C, Turnbull, Y, Erickson, J C, Marini, P, Wilson, D, McIntosh, A M, Adams, M J, Murgatroyd, C, Barrett, P, Delibegovic, M, Clarke, T-K & MacKenzie, A 2019, 'CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake', bioRxiv. https://doi.org/10.1101/572065ORCID: /0000-0003-3604-2950/work/78069883ORCID: /0000-0001-6193-3152/work/160847572ORCID: /0000-0002-8456-4473/work/177758636https://hdl.handle.net/2164/15816Acknowledgements We would like to thank Wenlong Huang, Giuseppe D’Agostino and the staff of the University of Aberdeen Medical Research Facility for their help and advice with the animal tests. AMcE was funded by BBSRC project grant (BB/N017544/1) and EH was funded by Medical Research Scotland (PhD-719-2013). PB and DW are funded by the Scottish Government Rural and Environment Science and Analytical Services Division to the Rowett Institute. Association studies were conducted using the UK Biobank Resource: application number 4844 and was supported by a Wellcome Trust Strategic Award ‘Stratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). Dedicated to the memory of my brother Angus MacKenzie (1963-2018).361544019engUK BiobankCRISPR genome editingtissue-specific enhancergalaninethanol intakeanxietyPKCEGR1R MedicineBiotechnology and Biological Sciences Research Council (BBSRC)BB/N017544/1Rural and Environmental Science and Analytical Services (RESAS)Wellcome Trust104036/Z/14/ZMedical Research Council (MRC)PhD-719-2013Supplementary DataRJournal article10.1101/572065