Synthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N-Terminal Domain

Henry, Martyn C.Riley, Christopher M.Hunter, IreneElwood, Jessica M. L.Lopez-Fernandez, J. DanielMinty, LauraCoe, Diane M.McEwan, Iain J.Jamieson, Craig2024-06-072024-06-072023-12-14Henry, M C, Riley, C M, Hunter, I, Elwood, J M L, Lopez-Fernandez, J D, Minty, L, Coe, D M, McEwan, I J & Jamieson, C 2023, 'Synthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N-Terminal Domain', ACS Medicinal Chemistry Letters, vol. 14, no. 12, pp. 1800 - 1806. https://doi.org/10.1021/acsmedchemlett.3c004261948-5875RIS: urn:78A57DC5C60EB8F1859E497AB3EE6C13https://hdl.handle.net/2164/23565Acknowledgments We thank Craig Irving for his assistance with NMR spectroscopy and Pat Keating, Dr. Jessica Bame, and Dr. Graeme Anderson for their assistance with HRMS.71763540engSDG 3 - Good Health and Well-beingProstate cancerAndrogen receptorIntrinsically disordered proteinR MedicineMedical Research Council (MRC)MR/T02559/XSupplementary InformationRSynthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N-Terminal DomainJournal article10.1021/acsmedchemlett.3c004261412