Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

Then, Chee KinPaillas, SalomeMoomin, AliuMisheva, Mariya D.Moir, Rachel A.Hay, Susan M.Bremner, DavidRoberts (nee Nellany), Kristine S.Smith, Ellen E.Heidari, ZeynabSescu, DanielWang, XuedanSuárez-Bonnet, AlejandroHay, NadineMurdoch, Sarah L.Saito, RyoichiCollie-Duguid, Elaina S. R.Richardson, ShirleyPriestnall, Simon L.Wilson, Joan M.Gurumurthy, MahalakshmiRoyle, Justine S.Samuel, Leslie M.Ramsay, GeorgeVallis, Katherine A.Foster, Kevin R.McCullagh, James S. O.Kiltie, Anne E.2024-05-142024-05-142024-05-14Then, C K, Paillas, S, Moomin, A, Misheva, M D, Moir, R A, Hay, S M, Bremner, D, Roberts (nee Nellany), K S, Smith, E E, Heidari, Z, Sescu, D, Wang, X, Suárez-Bonnet, A, Hay, N, Murdoch, S L, Saito, R, Collie-Duguid, E S R, Richardson, S, Priestnall, S L, Wilson, J M, Gurumurthy, M, Royle, J S, Samuel, L M, Ramsay, G, Vallis, K A, Foster, K R, McCullagh, J S O & Kiltie, A E 2024, 'Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity', Microbiome, vol. 12, no. 1, 89. https://doi.org/10.1186/s40168-024-01804-12049-2618RIS: urn:9FFBBFA1C0C81D3907F3833C90AA7F80ORCID: /0000-0002-8402-8670/work/159955479ORCID: /0000-0001-7208-2912/work/159955696ORCID: /0000-0003-3559-0584/work/159956091ORCID: /0000-0002-7511-4139/work/164095108https://hdl.handle.net/2164/23455Acknowledgements We thank Professor William Kim (University of North Carolina, Chapel Hill) for his generous gift of the UPPL1591 cell line. We thank Dr. Mark Hill (Department of Oncology, University of Oxford) for assistance with irradiation procedures, and Dr. Jia-Yu Ke and Dr. Vijay Indukuri (Research Diets, Inc.) for formulation of the mouse diets. We thank Dr. Graham Horgan (James Hutton Research Institute, Aberdeen) for statistical advice. We thank Grampian Biorepository at Aberdeen Royal Infirmary for providing the faecal samples from cancer patients.225422759engSDG 3 - Good Health and Well-beingRadiotherapyDietary fibreGut microbiotaShort-chain fatty acidsIsoferulic acidCancerimmunomodulationR MedicineWellcome TrustRG13793-55Cancer Research UKC5255/A23279A31475OtherSF10237-53Supplementary InformationRDietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicityJournal article10.1186/s40168-024-01804-1121