Wishart, Thomas MMutsaers, Chantal ARiessland, MarkusReimer, Michell MHunter, GillianHannam, Marie LEaton, Samantha LFuller, Heidi RRoche, Sarah LSomers, EilidhMorse, RobertYoung, Philip JLamont, Douglas JHammerschmidt, MatthiasJoshi, AnaghaHohenstein, PeterMorris, Glenn EParson, Simon HSkehel, Paul ABecker, ThomasRobinson, Iain MBecker, Catherina GWirth, BrunhildeGillingwater, Thomas H2014-09-022014-09-022014-04-01Wishart, T M, Mutsaers, C A, Riessland, M, Reimer, M M, Hunter, G, Hannam, M L, Eaton, S L, Fuller, H R, Roche, S L, Somers, E, Morse, R, Young, P J, Lamont, D J, Hammerschmidt, M, Joshi, A, Hohenstein, P, Morris, G E, Parson, S H, Skehel, P A, Becker, T, Robinson, I M, Becker, C G, Wirth, B & Gillingwater, T H 2014, 'Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy', The Journal of Clinical Investigation, vol. 124, no. 4, pp. 1821-1834. https://doi.org/10.1172/JCI713180021-9738ORCID: /0000-0002-8848-8738/work/82379640http://hdl.handle.net/2164/3424Acknowledgements The authors are grateful to Nils Lindstrom and members of the Gillingwater laboratory for advice and assistance with this study and helpful comments on the manuscript; Neil Cashman for the NSC-34 cell line; and Ji-Long Liu for the DrosophilasmnA and smnB lines. This work was supported by grants from the SMA Trust (to T.H. Gillingwater, P.J. Young, and R. Morse), BDF Newlife (to T.H. Gillingwater and S.H. Parson), the Anatomical Society (to T.H. Gillingwater and S.H. Parson), the Muscular Dystrophy Campaign (to T.H. Gillingwater), the Jennifer Trust for Spinal Muscular Atrophy (to H.R. Fuller), the Muscular Dystrophy Association (to G.E. Morris), the Vandervell Foundation (to P.J. Young), the Medical Research Council (GO82208 to I.M. Robinson), Roslin Institute Strategic Grant funding from the BBSRC (to T.M. Wishart), the BBSRC (to C.G. Becker), the Deutsche Forschungsgemeinschaft and EU FP7/2007-2013 (grant no. 2012-305121, NeurOmics, to B. Wirth), the Center for Molecular Medicine Cologne (to B. Wirth and M. Hammerschmidt), and SMA Europe (to M.M. Reissland). We would also like to acknowledge financial support to the Gillingwater lab generated through donations to the SMASHSMA campaign.144503859engsurvival-motor-neuronmouse modelSMN proteinneuromuscular-junctioncircuit functiondefectsgenecellsdrosophilapathologyR MedicineQH301 BiologyMedical Research Council (MRC)GO82208Biotechnology and Biological Sciences Research Council (BBSRC)European CommissionFP7/2007-20132012-305121Supplementary DataRQH301Journal article10.1172/JCI713181244