Cano-Gamez, EddieBurnham, Katie L.Goh, CyndiAllcock, AliceMalick, Zunaira H.Overend, LaurenKwok, AndrewSmith, David A.Peters-Sengers, HesselAntclife, DavidMcKechnie, StuartScicluna, Brendon P.van der Poll, TomGordon, Anthony C.Hinds, Charles J.Davenport, Emma E.Knight, Julian C.Webster, NigelGalley, HelenTaylor, JaneHall, SallyAddison, JenniRoughton, SianTennant, HeatherGuleri, AchyutWaddington, NataliaArawwawala, DilshanDurcan, JohnShort, AlasdairSwan, KarenWilliams, SarahSmolen, SusanMitchell-Inwang, ChristineGordon, TonyErrington, EmilyTempleton, MaieVenatesh, PydaWard, GeraldineMcCauley, MarieBaudouin, SimonHigham, CharleySoar, JasmeetGrier, SallyHall, ElaineBrett, StephenKitson, DavidWilson, RobertMountford, LauraMoreno, JuanHall, PeterGAinS Investigators2023-07-242023-07-242022-11-02Cano-Gamez, E, Burnham, K L, Goh, C, Allcock, A, Malick, Z H, Overend, L, Kwok, A, Smith, D A, Peters-Sengers, H, Antclife, D, McKechnie, S, Scicluna, B P, van der Poll, T, Gordon, A C, Hinds, C J, Davenport, E E, Knight, J C, Webster, N, Galley, H, Taylor, J, Hall, S, Addison, J, Roughton, S, Tennant, H, Guleri, A, Waddington, N, Arawwawala, D, Durcan, J, Short, A, Swan, K, Williams, S, Smolen, S, Mitchell-Inwang, C, Gordon, T, Errington, E, Templeton, M, Venatesh, P, Ward, G, McCauley, M, Baudouin, S, Higham, C, Soar, J, Grier, S, Hall, E, Brett, S, Kitson, D, Wilson, R, Mountford, L, Moreno, J, Hall, P & GAinS Investigators 2022, 'An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression', Science translational medicine, vol. 14, no. 669, eabq4433. https://doi.org/10.1126/scitranslmed.abq44331946-6234https://hdl.handle.net/2164/21281Funding Information: This work was funded in whole, or in part, by the Medical Research Council (MR/V002503/1) (J.C.K. and E.E.D.); Wellcome Trust Investigator Award (204969/Z/16/Z) (J.C.K.); Wellcome Trust core funding to the Wellcome Sanger Institute (grant numbers 206194 and 108413/A/15/D); Wellcome Trust grants (090532/Z/09/Z and 203141/Z/16/Z) to core facilities; Wellcome Centre for Human Genetics; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant number: 2018-I2M-2-002); and National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (J.C.K.). A.C.G. is supported by an NIHR Research Professor award (RP-2015-06-018) and the NIHR Imperial Biomedical Research Center. We thank all the patients, patient families, nurses, and clinicians who participated in the GAinS and MARS studies; and the COMBAT Consortium, MOSAIC Consortium, and DeCOI.363674568engAdultHumansChildInfluenza A Virus, H1N1 SubtypeGene Expression ProfilingCOVID-19Sepsis/geneticsTranscriptome/geneticsR MedicineGeneral MedicineMedical Research Council (MRC)MR/V002503/1Wellcome Trust206194108413/A/15/D090532/Z/09/Z203141/Z/16/ZNational Institute for Health Research (NIHR)RP-2015-06-018Supplementary DataRJournal article10.1126/scitranslmed.abq4433http://www.scopus.com/inward/record.url?scp=85142089291&partnerID=8YFLogxKhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613832/14669