Wagner, StefanBrierley, Daniel ILeeson-Payne, AlasdairJiang, WanqingChianese, RaffaellaLam, Brian Y HDowsett, Georgina K CCristiano, ClaudiaLyons, DavidReimann, FrankGribble, Fiona MMartinez de Morentin, Pablo BYeo, Giles S HTrapp, StefanHeisler, Lora K2023-02-062023-02-062023-02Wagner, S, Brierley, D I, Leeson-Payne, A, Jiang, W, Chianese, R, Lam, B Y H, Dowsett, G K C, Cristiano, C, Lyons, D, Reimann, F, Gribble, F M, Martinez de Morentin, P B, Yeo, G S H, Trapp, S & Heisler, L K 2023, 'Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression', Molecular Metabolism, vol. 68, 101665. https://doi.org/10.1016/j.molmet.2022.1016652212-8778ORCID: /0000-0002-1823-2913/work/128322172ORCID: /0000-0002-0684-3215/work/127118034https://hdl.handle.net/2164/19993Acknowledgements The authors thank Dr Alasdair S. Garfield, and staff within the University of Aberdeen Medical Research Facility and the Microscopy Facility for their technical assistance. pAAV-mCherry-flex-dtA was a gift from Naoshige Uchida. Work was supported by the Biotechnology and Biological Sciences Research Council (BB/R01857X/1, BB/V016849/1 to LKH and BB/S017593/1 to BYHL), the European Foundation for the Study of Diabetes (Merck Sharpe Dohme grant to ST), the Medical Research Council (MC/PC/15077 to LKH, MR/N02589X/1 to ST and MRC_MC_UU_12012/3 to FR and FMG, and MC_UU_00014/1 to GSHY), the NIH (R01 DK095757 to ST), the Wellcome Trust (WT081713 to LKH, 106262/Z/14/Z, 106263/Z/14/Z to FR and FMG, and 223279/Z/21/Z to DIB) and the Wellcome Trust Institutional Strategic Support Fund to the University of Aberdeen (204815/Z/16/Z to LKH). Next-generation sequencing was performed by IMS Genomics and transcriptomics core facility, which is supported by the MRC (MC_UU_00014/5) and the Wellcome Trust (208363/Z/17/Z), and the Cancer Research UK Cambridge Institute Genomics Core. GKCD is funded by a BBSRC CASE 4-year PhD studentship, co-funded by Novo Nordisk. WJ is supported by a UCL ORS scholarship and a CSC scholarship from the Chinese Government.113486629engSDG 3 - Good Health and Well-beingLorcaserinLiraglutidePreproglucagonNucleus tractus solitariiBrainstemSerotonin 2C receptorR MedicineMedical Research Council (MRC)MR/N02589X/1MC/PC/15077MRC_MC_UU_12012/3Biotechnology and Biological Sciences Research Council (BBSRC)B/R01857X/1BB/V016849/1BB/S017593/1Wellcome TrustWT081713106262/Z/14/Z106263/Z/14/Z223279/Z/21/Z208363/Z/17/ZRJournal article10.1016/j.molmet.2022.10166568