Applied Health Sciences (Department)
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Item Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke(2019) McHutchison, C. A.; Cvoro, V.; Makin, S.; Chappell, F. M.; Shuler, K.; Wardlaw, J. M.; University of Aberdeen.Other Applied Health SciencesItem Anti-cholinergic burden and patient related clinical outcomes in an emergency general surgical setting(2019-04) Ablett, Andrew D.; Browning, Aimee; Quan, Vincent; Tay, Hui S.; McCormack, Caroline; Carter, Ben; Hewitt, Jonathan; Myint, Phyo K.; Older Persons Surgical Outcomes Collaboration (OPSOC); University of Aberdeen.Applied Medicine; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Institute of Applied Health SciencesItem Patient and public involvement (PPI) in UK surgical trials : a survey and focus groups with stakeholders to identify practices, views and experiences(2019-02-11) Crocker, Joanna C.; Pratt-Boyden, Keira; Hislop, Jenny; Rees, Sian; Locock, Louise; Olszowski, Sophie; Chant, Alan; Treweek, Shaun; Cook, Jonathan A.; Woolfall, Kerry; Farrar, Nicola; Bostock, Jennifer; Bulbulia, Richard; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem Fractures in Adults After Weight Loss from Bariatric Surgery and Weight Management Programs for Obesity : Systematic Review and Meta-analysis(2019-04) Ablett, Andrew D.; Boyle, Bonnie R; Avenell, Alison; University of Aberdeen.Aberdeen Centre for Evaluation; University of Aberdeen.Institute of Applied Health SciencesItem Which factors predict success in the mandatory UK postgraduate surgical exam : The Intercollegiate Membership of the Royal College of Surgeons (MRCS)?(2018-08) Scrimgeour, D. S.G.; Cleland, J.; Lee, A. J.; Brennan, P. A.; University of Aberdeen.Applied Medicine; University of Aberdeen.Centre for Healthcare Education and Research Innovation (CHERI); University of Aberdeen.Medical Education; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical StatisticsItem Developing and validating Parkinson's disease subtypes and their motor and cognitive progression(2018-12) Lawton, Michael; Ben-Shlomo, Yoav; May, Margaret T.; Baig, Fahd; Barber, Thomas R.; Klein, Johannes C.; Swallow, Diane M.A.; Malek, Naveed; Grosset, Katherine A.; Bajaj, Nin; Barker, Roger A.; Williams, Nigel; Burn, David J.; Foltynie, Thomas; Morris, Huw R.; Wood, Nicholas W.; Grosset, Donald G.; Hu, Michele T.M.; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.University of Aberdeen; University of Aberdeen.Other Applied Health SciencesItem Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial : FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study)(BMC, 2008-11-03) Lois, Noemi; Burr, Jennifer Margaret; Norrie, John David; Vale, Luke David; Cook, Jonathan Alistair; McDonald, Alison Mary; FILMS Group; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health SciencesBackground: A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and post-operative intraocular tamponade with gas, is effective for stage 2, 3 and 4 FTMH. Internal limiting membrane (ILM) peeling has been introduced as an additional surgical manoeuvre to increase the success of the surgery; i.e. increase rates of hole closure and visual improvement. However, little robust evidence exists supporting the superiority of ILM peeling compared with no-peeling techniques. The purpose of FILMS (Fullthickness macular hole and Internal Limiting Membrane peeling Study) is to determine whether ILM peeling improves the visual function, the anatomical closure of FTMH, and the quality of life of patients affected by this disorder, and the cost-effectiveness of the surgery. Methods/Design: Patients with stage 2–3 idiopathic FTMH of less or equal than 18 months duration (based on symptoms reported by the participant) and with a visual acuity ≤ 20/40 in the study eye will be enrolled in this FILMS from eight sites across the UK and Ireland. Participants will be randomised to receive combined cataract surgery (phacoemulsification and intraocular lens implantation) and pars plana vitrectomy with postoperative intraocular tamponade with gas, with or without ILM peeling. The primary outcome is distance visual acuity at 6 months. Secondary outcomes include distance visual acuity at 3 and 24 months, near visual acuity at 3, 6, and 24 months, contrast sensitivity at 6 months, reading speed at 6 months, anatomical closure of the macular hole at each time point (1, 3, 6, and 24 months), health related quality of life (HRQOL) at six months, costs to the health service and the participant, incremental costs per quality adjusted life year (QALY) and adverse events. Discussion: FILMS will provide high quality evidence on the role of ILM peeling in FTMH surgery. Trial registration: This trial is registered with Current Controlled Trials ISRCTN number 33175422 and Clinical Trials.gov identifier NCT00286507.Item Recruitment to publicly funded trials - are surgical trials really different?(Elsevier, 2008-09) Cook, Jonathan Alistair; Ramsay, Craig R; Norrie, John David; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health SciencesGood recruitment is integral to the conduct of a high-quality randomised controlled trial. It has been suggested that recruitment is particularly difficult for evaluations of surgical interventions, a field in which there is a dearth of evidence from randomised comparisons. While there is anecdotal speculation to support the inference that recruitment to surgical trials is more challenging than for medical trials we are unaware of any formal assessment of this. In this paper, we compare recruitment to surgical and medical trials using a cohort of publicly funded trials. Data: Overall recruitment to trials was assessed using of a cohort of publicly funded trials (n = 114). Comparisons were made by using the Recruitment Index, a simple measure of recruitment activity for multicentre randomised controlled trials. Recruitment at the centre level was also investigated through three example surgical trials. Results: The Recruitment Index was found to be higher, though not statistically significantly, in the surgical group (n = 18, median = 38.0 IQR (10.7, 77.4)) versus (n = 81, median = 34.8 IQR (11.7, 98.0)) days per recruit for the medical group (median difference 1.7 (− 19.2, 25.1); p = 0.828). For the trials where the comparison was between a surgical and a medical intervention, the Recruitment Index was substantially higher (n = 6, 68.3 (23.5, 294.8)) versus (n = 93, 34.6 (11.7, 90.0); median difference 25.9 (− 35.5, 221.8); p = 0.291) for the other trials. Conclusions: There was no clear evidence that surgical trials differ from medical trials in terms of recruitment activity. There was, however, support for the inference that medical versus surgical trials are more difficult to recruit to. Formal exploration of the recruitment data through a modelling approach may go some way to tease out where important differences exist.Item Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery(Elsevier, 2007) Cuthbertson, Brian; Amiri, Amir R.; Croal, Bernard L.; Rajagopalan, Sriram; Brittenden, Julie; Hillis, Graham S.; University of Aberdeen, School of Medicine & Dentistry, Division of Applied Health Sciences; University of Aberdeen, School of Medicine & Dentistry, Division of Applied MedicineWe assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery. During a median 654 days follow-up 33 patients from a total cohort of 204 patients (16%) died. The optimal cut-off in this cohort, determined using a receiver operating characteristic curve, was >35pg.mL-1. This was associated with a 3.47-fold increase in the hazard of death (p=0.001) and had a sensitivity of 70% and a specificity of 68% for this outcome. These findings extend recent work demonstrating that BNP levels obtained before major noncardiac surgery can be used to predict peri-operative morbidity, and indicate that they also forecast medium-term mortality.