Applied Health Sciences (Department)
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Item Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability(2019-05-22) McHutchison, Caroline A.; Chappell, Francesca M; Makin, Stephen; Shuler, Kirsten; Wardlaw, Joanna M; Cvoro, Vera; University of Aberdeen.Other Applied Health SciencesItem The brain health index : Towards a combined measure of neurovascular and neurodegenerative structural brain injury(2018-10-01) Dickie, David Alexander; Valdes Hernandez, Maria del C; Makin, Stephen D; Staals, Julie; Wiseman, Stewart J; Bastin, Mark E; Wardlaw, Joanna M; University of Aberdeen.Other Applied Health SciencesItem Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke(2019-03-14) Valdes Hernandez, Maria del C. Valdés; Case, Tessa; Chappell, Francesca M; Glatz, Andreas; Makin, Stephen; Doubal, Fergus; Wardlaw, Joanna M; University of Aberdeen.Other Applied Health SciencesItem Dietary iodine exposure and brain structures and cognition in older people : Exploratory analysis in the Lothian Birth Cohort 1936(2017-11) Hernández, Maria del C. Valdés; Kyle, Janet; Allan, Julia; Allerhand, Michael; Clark, Heather; Maniega, Susana Muñoz; Royle, Natalie A.; Gow, Alan J; Pattie, Alison; Corley, Janie; Bastin, Martin E.; Starr, John M; Wardlaw, Joanna M.; Deary, Ian J.; Combet, Emilie; University of Aberdeen.Institute of Applied Health Sciences; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Aberdeen Health Psychology GroupItem Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms : A cohort study in late life(2016-03) Murray, Alison; McNeil, Chris; Salarirad, Sima; Deary, Ian; Phillips, Louise; Whalley, Lawrence; Staff, Roger; University of Aberdeen.Grampian Data Safe Haven (DaSH); University of Aberdeen.Applied Medicine; University of Aberdeen.Aberdeen Biomedical Imaging Centre; University of Aberdeen.Psychology; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical SciencesItem Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials(Blackwell, 2008) Jia, X; McNeill, G; Avenell, AlisonBackground Observational studies have shown associations between nutritional status and cognition in later life but evidence from intervention studies is unclear. The present study systematically reviewed the evidence on the effect of nutrient supplementation on cognitive function in people aged ≥65 years. Methods Databases including MEDLINE and EMBASE were searched up to 1 September 2006. Randomized controlled trials using at least one kind of vitamin, mineral or omega-3 fatty acid, evaluating standardized neuropsychological test(s), were included. There were no restrictions on participants' baseline nutritional status or cognitive function. Quality assessment and data abstraction were conducted by one author and checked by another. Results Of 4229 articles retrieved, 22 trials (3442 participants) were identified. Many were small, short duration and of poor methodology. Only 16 out of 122 cognitive tests were significantly different between groups. A meta-analysis showed no significant effect of taking B vitamins or antioxidant vitamins on global cognitive function. There was insufficient evidence to evaluate the effect of omega-3 fatty acids on any cognitive domains. Conclusion There was little evidence of a beneficial effect from taking B vitamins or antioxidant supplements on global cognitive function in later life. Larger-scale randomized controlled trials of longer duration in selected age groups are needed.