Applied Health Sciences (Department)
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Item The British Society for Rheumatology Biologics Registers in Ankylosing Spondylitis (BSRBR-AS) study : Protocol for a prospective cohort study of the long-term safety and quality of life outcomes of biologic treatment(2015-11-11) Macfarlane, Gary J; Barnish, Maxwell S; Jones, Elizabeth A; Kay, Lesley; Keat, Andrew; Meldrum, Karen T; Pathan, Ejaz; Sturrock, Roger D; Zabke, Claudia; McNamee, Paul; Jones, Gareth T; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Epidemiology Group; University of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH); University of Aberdeen.Medical Education; University of Aberdeen.Health Economics Research Unit; University of Aberdeen.Institute of Applied Health SciencesItem Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease(2015-01-22) Wischik, Claude M; Staff, Roger T; Wischik, Damon J; Bentham, Peter; Murray, Alison D; Storey, John M D; Kook, Karin A; Harrington, Charles R; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Medical Sciences; University of Aberdeen.Applied Medicine; University of Aberdeen.Grampian Data Safe Haven (DaSH); University of Aberdeen.Aberdeen Biomedical Imaging Centre; University of Aberdeen.ChemistryItem "New" and distributed leadership in quality and safety in healthcare, or "old" and hierarchical? : An interview study with strategic stakeholders(2013-10) McKee, Lorna; Charles, Kathryn; Dixon-Woods, Mary; Willars, Janet; Martin, Graham; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Business ManagementItem Systematic review of the safety and efficacy of foam sclerotherapy for venous disease of the lower limbs(2007-08) Jia, X.; Mowatt, Graham; Burr, Jennifer Margaret; Cassar, Kevin; Cook, Jonathan Alistair; Fraser, Cynthia Mary; University of Aberdeen.Other Applied Health SciencesItem Systematic review of the efficacy and safety of using mesh in surgery for uterine or vaginal vault prolapse(2010-11-01) Jia, Xueli; Glazener, Cathryn M A; Mowatt, Graham; Jenkinson, David; Fraser, Cynthia; Bain, Christine; Burr, Jennifer; University of Aberdeen.Other Applied Health Sciences; University of Aberdeen.Aberdeen Centre for EvaluationItem Efficacy and safety of using mesh or grafts in surgery for anterior and/or posterior vaginal wall prolapse: systematic review and meta-analysis.(Elsevier Science, 2008) Jia, Xueli; Glazener, Cathryn Margaret Anne; Mowatt, Graham; MacLennan, Graeme Stewart; Fraser, Cynthia Mary; Bain, Christine; Burr, Jennifer MargaretBackground The efficacy and safety of mesh/graft in surgery for anterior or posterior pelvic organ prolapse is uncertain. Objectives To systematically review the efficacy and safety of mesh/graft for anterior or posterior vaginal wall prolapse surgery. Search strategy Electronic databases and conference proceedings were searched, experts and manufacturers contacted and reference lists of retrieved papers scanned. Selection criteria Randomised controlled trials (RCTs), non-randomised comparative studies, registries, case series involving at least 50 women, and RCTs published as conference abstracts from 2005 onwards. Data collection and analysis One reviewer screened titles/abstracts, undertook data extraction, and assessed study quality. Data analysis was conducted for three subgroups: anterior, posterior, and anterior and/or posterior repair (not reported separately). Results Forty-nine studies involving 4569 women treated with mesh/graft were included. Study quality was generally high. Median follow up was 13 months (range 1 to 51). In anterior repair, there was short-term evidence that mesh/graft (any type) significantly reduced objective prolapse recurrence rates compared with no mesh/graft (relative risk 0.48, 95% CI 0.32-0.72). Non-absorbable synthetic mesh had a significantly lower objective prolapse recurrence rate (8.8%, 48/548) than absorbable synthetic mesh (23.1%, 63/273) and biological graft (17.9%, 186/1041), but a higher erosion rate (10.2%, 68/666) than synthetic mesh (0.7%, 1/147) and biological graft (6.0%, 35/581). There was insufficient information to compare any of the other outcomes regardless of prolapse type. Conclusion Evidence for most outcomes was too sparse to provide meaningful conclusions. Rigorous long-term RCTs are required to determine the comparative efficacy of using mesh/graft.