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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

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dc.contributor.authorBergamaschi, Laura
dc.contributor.authorMescia, Federica
dc.contributor.authorTurner, Lorinda
dc.contributor.authorHanson, Aimee L.
dc.contributor.authorKotagiri, Prasanti
dc.contributor.authorDunmore, Benjamin J.
dc.contributor.authorRuffieux, Hélène
dc.contributor.authorSa, Aloka De
dc.contributor.authorHuhn, Oisín
dc.contributor.authorMorgan, Michael D.
dc.contributor.authorGerber, Pehuén Pereyra
dc.contributor.authorWills, Mark R.
dc.contributor.authorBaker, Stephen
dc.contributor.authorCalero-Nieto, Fernando J.
dc.contributor.authorDoffinger, Rainer
dc.contributor.authorDougan, Gordon
dc.contributor.authorElmer, Anne
dc.contributor.authorGoodfellow, Ian G.
dc.contributor.authorGupta, Ravindra K.
dc.contributor.authorHosmillo, Myra
dc.contributor.authorHunter, Kelvin
dc.contributor.authorKingston, Nathalie
dc.contributor.authorLehner, Paul J.
dc.contributor.authorMatheson, Nicholas J.
dc.contributor.authorNicholson, Jeremy K.
dc.contributor.authorPetrunkina, Anna M.
dc.contributor.authorRichardson, Sylvia
dc.contributor.authorSaunders, Caroline
dc.contributor.authorThaventhiran, James E.D.
dc.contributor.authorToonen, Erik J.M.
dc.contributor.authorWeekes, Michael P.
dc.contributor.authorGöttgens, Berthold
dc.contributor.authorToshner, Mark
dc.contributor.authorHess, Christoph
dc.contributor.authorBradley, John R.
dc.contributor.authorLyons, Paul A.
dc.contributor.authorSmith, Kenneth G.C.
dc.contributor.authorCambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-03-09T17:43:01Z
dc.date.available2023-03-09T17:43:01Z
dc.date.issued2021-06-08
dc.descriptionAcknowledgements We thank all the patients and health care workers who consented to take part in this study. We are grateful to CVC Capital Partners, the Evelyn Trust (20/75), Addenbrooke's Charitable Trust, Cambridge University Hospitals (12/20A), the NIHR Cambridge Biomedical Research Centre, and the UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC) for their financial support. Further support: K.G.C.S.: Wellcome Investigator Award (200871/Z/16/Z); M.P.W.: Wellcome Senior Clinical Research Fellowship (108070/Z/15/Z); C.H.: Wellcome COVID-19 Rapid Response DCF and the Fondation Botnar; N.M.: MRC (CSF MR/P008801/1), NHSBT (WPA15-02), and Addenbrooke's Charitable Trust, (grant ref. to 900239 NJM); I.G.G.: Wellcome Senior Fellowship and Wellcome grant (Ref: 207498/Z/17/Z); P.J.L.: Wellcome Trust Principal Research Fellowship (084957/Z/08/Z) and MRC (MR/V011561/1); J.K.N.: The Spinnaker Healthcare Research Trust and the McCusker Foundation as part of Australian National Phenome Centre. P.K. is the recipient of a Jacquot Research Entry Scholarship of the Royal Australasian College of Physicians Foundation. We would like to thank the NIHR Cambridge Clinical Research Facility outreach team for enrollment of patients; the NIHR Cambridge Biomedical Research Centre Cell Phenotyping Hub and the CRUK Cambridge Institute flow cytometry core facility for flow and mass cytometry; and the Cambridge NIHR BRC Stratified Medicine Core Laboratory NGS Hub (supported by an MRC Clinical Infrastructure Award) for RNA sequencing.en
dc.description.statusPeer revieweden
dc.format.extent28
dc.format.extent4408947
dc.identifier221553977
dc.identifiere615dd19-dc0d-4c4e-b14b-59034945f403
dc.identifier85107023094
dc.identifier.citationBergamaschi, L, Mescia, F, Turner, L, Hanson, A L, Kotagiri, P, Dunmore, B J, Ruffieux, H, Sa, A D, Huhn, O, Morgan, M D, Gerber, P P, Wills, M R, Baker, S, Calero-Nieto, F J, Doffinger, R, Dougan, G, Elmer, A, Goodfellow, I G, Gupta, R K, Hosmillo, M, Hunter, K, Kingston, N, Lehner, P J, Matheson, N J, Nicholson, J K, Petrunkina, A M, Richardson, S, Saunders, C, Thaventhiran, J E D, Toonen, E J M, Weekes, M P, Göttgens, B, Toshner, M, Hess, C, Bradley, J R, Lyons, P A, Smith, K G C & Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) Covid BioResource Collaboration 2021, 'Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease', Immunity, vol. 54, no. 6, pp. 1257-1275.e8. https://doi.org/10.1016/j.immuni.2021.05.010en
dc.identifier.doi10.1016/j.immuni.2021.05.010
dc.identifier.iss6en
dc.identifier.issn1074-7613
dc.identifier.otherORCID: /0000-0003-0757-0711/work/94584961
dc.identifier.urihttps://hdl.handle.net/2164/20265
dc.identifier.urlhttps://doi.org/10.1016/j.immuni.2021.05.010en
dc.identifier.urlhttps://europepmc.org/article/PMC/PMC8125900en
dc.identifier.vol54en
dc.language.isoeng
dc.relation.ispartofImmunityen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectSARS-CoV-2en
dc.subjectCOVID-19en
dc.subjectbystander CD8+ T cellen
dc.subjectrecoveryen
dc.subjectimmune pathologyen
dc.subjectsystemic inflammationen
dc.subjectcomplementen
dc.subjectTNF-αen
dc.subjectinterferonen
dc.subjectR Medicineen
dc.subjectQR180 Immunologyen
dc.subjectImmunology and Allergyen
dc.subjectCell Biologyen
dc.subjectInfectious Diseasesen
dc.subjectBiochemistryen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectUK Research and Innovation (UKRI)en
dc.subjectWellcome Trusten
dc.subject200871/Z/16/Zen
dc.subject108070/Z/15/Zen
dc.subject207498/Z/17/Zen
dc.subject084957/Z/08/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectCSF MR/P008801/1en
dc.subjectMR/V011561/1en
dc.subjectOtheren
dc.subjectWPA15-02en
dc.subject900239en
dc.subjectSupplementary Dataen
dc.subjecthttps://www.covid19cellatlas.org/patient/citiid/en
dc.subjectEGAS00001005332en
dc.subjectFR-FCM-Z3XQen
dc.subjectFR-FCM-Z3SRen
dc.subjectFR-FCM-Z3STen
dc.subjectFR-FCM-Z3SSen
dc.subjectE-MTAB-10026en
dc.subject.lccRen
dc.subject.lccQR180en
dc.titleLongitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild diseaseen
dc.typeJournal articleen

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