Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

Al-Wahaibi, Lamya H.; Mohammed, Anber F.; Abdel Rahman, Fatema El Zahraa S.; Abdelrahman, Mostafa H.; Gu, Xuyuan; Trembleau, Laurent; Youssif, Bahaa G.M.

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

Files

Al_Wahaibi_etal_JEIAMC_Design_Synthesis_Apoptotic_VOR.pdf (2.42 MB)

Date

2023-05-31

Authors

Al-Wahaibi, Lamya H.

Mohammed, Anber F.

Abdel Rahman, Fatema El Zahraa S.

Abdelrahman, Mostafa H.

Gu, Xuyuan

Trembleau, Laurent

Youssif, Bahaa G.M.

Citation

Al-Wahaibi, L H, Mohammed, A F, Abdel Rahman, F E Z S, Abdelrahman, M H, Gu, X, Trembleau, L & Youssif, B G M 2023, 'Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR WT/ EGFR T790M inhibitors', Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 1, 2218602. https://doi.org/10.1080/14756366.2023.2218602