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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

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dc.contributor.authorAl-Wahaibi, Lamya H.
dc.contributor.authorMohammed, Anber F.
dc.contributor.authorAbdel Rahman, Fatema El Zahraa S.
dc.contributor.authorAbdelrahman, Mostafa H.
dc.contributor.authorGu, Xuyuan
dc.contributor.authorTrembleau, Laurent
dc.contributor.authorYoussif, Bahaa G.M.
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Natural & Computing Sciencesen
dc.date.accessioned2023-06-20T11:42:01Z
dc.date.available2023-06-20T11:42:01Z
dc.date.issued2023-05-31
dc.descriptionFunding This work was funded by Princess Nourah Bint Abdulrahman University Researchers Supporting Project Number [PNURSP2023R3], Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.en
dc.description.statusPeer revieweden
dc.format.extent1
dc.format.extent2536510
dc.identifier256751805
dc.identifier972e4fc8-534f-4485-a9a8-85e35832e74f
dc.identifier85160634957
dc.identifier37254958
dc.identifier.citationAl-Wahaibi, L H, Mohammed, A F, Abdel Rahman, F E Z S, Abdelrahman, M H, Gu, X, Trembleau, L & Youssif, B G M 2023, 'Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR WT/ EGFR T790M inhibitors', Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 1, 2218602. https://doi.org/10.1080/14756366.2023.2218602en
dc.identifier.doi10.1080/14756366.2023.2218602
dc.identifier.iss1en
dc.identifier.issn1475-6374
dc.identifier.otherORCID: /0000-0001-6376-9077/work/137297622
dc.identifier.urihttps://hdl.handle.net/2164/20935
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85160634957&partnerID=8YFLogxKen
dc.identifier.vol38en
dc.language.isoeng
dc.relation.ispartofJournal of enzyme inhibition and medicinal chemistryen
dc.subjectADMEen
dc.subjectantiproliferativeen
dc.subjectapoptosisen
dc.subjectEGFRen
dc.subjectIndoleen
dc.subjectmutationen
dc.subjectresistanceen
dc.subjectRS Pharmacy and materia medicaen
dc.subjectPharmacologyen
dc.subjectDrug Discoveryen
dc.subjectSupplementary Informationen
dc.subject.lccRSen
dc.titleDesign, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitorsen
dc.typeJournal articleen

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